Pharmacology for Nurses: Practical Applications (GI Mucosa)

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Chapter 44: Anti-Inflammatory Test, Patient, Nurse, Pharmacology, Maintain GI Mucosa

The key terms in this Pharmacology course include Anti-Inflammatory Test, Patient, Nurse, Pharmacology, Maintain GI Mucosa, COX-2 inhibitors, Allopurinol, Herbal and Dietary Supplements, Increase Your Fluid Intake, Arthritis Pain, Acetylsalicylic Acid, Acute Postoperative Pain, NSAID, Flulike symptoms


A nurse teaching a patient receiving allopurinol would include what information?

“Include salmon and organ meats in your diet on a weekly basis.”

“This medication may cause your urine to turn orange.”

“Take the medication with an antacid to minimize GI distress.”

“Increase your fluid intake to 3 L per day.”

Patients taking allopurinol should be informed to increase fluid intake to 3 L per day, avoid hazardous activities if dizziness or drowsiness occurs with the medication, and avoid the use of alcohol and caffeine because these drugs will increase uric acid levels and decrease the levels of allopurinol.


The patient asks the nurse about the use of herbal and dietary supplements to treat arthritis pain. What is the appropriate response by the nurse?

“There really are no safe herbal treatments for pain. Your best action would be to take your prescription medications.”

“There is evidence that glucosamine sulfate with chondroitin does decrease joint stiffness and pain. Discuss this with your health care provider.”

“High doses of vitamins and minerals have been used for many years to help maintain joint health.”

“Ginkgo biloba has shown tremendous benefit as an antiinflammatory drug and is used to treat the symptoms of pain.”

There is evidence that patients would benefit from glucosamine sulfate and chondroitin supplements to decrease the pain of osteoarthritis. However, they should always be used in consultation with a health care provider.


What is an advantage of COX-2 inhibitors over other NSAIDs?

Rapid onset of action

Less likely to cause hepatic toxicity

Longer duration of action

Maintain GI mucosa

By not inhibiting the COX-1 enzyme to maintain an intact gastric mucosal barrier by increasing secretion of mucus, the risks of GI adverse effects are decreased.


The nurse would question a prescription to administer acetylsalicylic acid to what patient?

18-year-old patient with a history of sports injury

42-year-old patient with a history of stroke

35-year-old patient with a history of heart attack

7-year-old patient with a history of flulike symptoms

Aspirin should never be administered to children with flulike symptoms. The use of aspirin in children with flulike symptoms has been associated with Reye’s syndrome.


What NSAID would the nurse anticipate administering parenterally for the treatment of acute postoperative pain?

Allopurinol

Indomethacin

Diclofenac

Ketorolac

Ketorolac can be administered by injection (intramuscularly or intravenously) and is indicated for the short-term treatment of moderate to severe acute pain.


What is an advantage of COX-2 inhibitors over other NSAIDs?

Maintain GI mucosa

Less likely to cause hepatic toxicity

Longer duration of action

Rapid onset of action

By not inhibiting the COX-1 enzyme to maintain an intact gastric mucosal barrier by increasing secretion of mucus, the risks of GI adverse effects are decreased.