Anti-inflammatory – Pharmacology for Nurses: Practical Apps

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Chapter 44: Anti-Inflammatory Test, Pharmacology for Nurses: Practical Applications

The key terms in this Pharmacology course include Anti-Inflammatory Test, Patient, Nurse, Acid, Adverse Effect, Pharmacology, Action, Nonsteroidal Antiinflammatory Drugs (NSAIDs), Inhibiting Prostaglandin Production, Gout, Colchicine, Medication, Acetic Acid Derivative Indomethacin

What is the mechanism of action of nonsteroidal antiinflammatory drugs (NSAIDs)?

Increasing blood flow to painful areas

Enhancing pain perception

Inhibiting prostaglandin production

Increasing the supply of natural endorphins

Prostaglandins are produced in response to activation of the arachidonic pathway. NSAIDs work by blocking cyclooxygenase (COX-1 and COX-2), the enzyme responsible for conversion of arachidonic acid into prostaglandins. Decreasing the synthesis of prostaglandins results in decreased pain and inflammation.

The nurse is educating a patient with gout. The nurse explains the action of colchicine to the patient. What statement is accurate in discussing the therapeutic action of the medication?

Decreases mobility of leukocytes

Decreases production of lactic acid

Increases process of phagocytosis

Increases uric acid metabolism

Colchicine works by inhibiting the metabolism and migration of leukocytes into joints affected by gout, thus resulting in decreased inflammation.

The acetic acid derivative indomethacin has what properties? (Select all that apply.)






The nurse would question a prescription to administer misoprostol to a patient with what condition?

Gastroesophageal reflux disease

Chronic obstructive pulmonary disease


Peptic ulcer

Misoprostol is an abortifacient and thus is contraindicated in pregnancy.

When teaching a patient about potential adverse effects of NSAID therapy, the nurse will teach the patient to immediately notify the health care provider of what effect?

Mild indigestion

Nonproductive cough


Black tarry stools

A major adverse effect of NSAID therapy is gastrointestinal (GI) distress with potential GI bleeding. Black or tarry stools are indicative of a GI bleed.

The nurse is administering probenecid to a patient with recurrent strep throat. The nurse teaches the patient that the reason for taking this medication is for what drug effect?

Increase uric acid excretion

Inhibit bacterial growth and replication

Prolong the effectiveness of penicillin therapy

Prevent the occurrence of gout

Besides its use for the treatment of the hyperuricemia associated with gout and gouty arthritis, probenecid also has the ability to delay the renal excretion of penicillin, thus increasing serum levels of penicillin and prolonging its effect.

What nursing diagnosis is appropriate for a patient prescribed colchicine?

Constipation related to adverse effect of the medication

Risk for infection related to medication-induced leukocytosis

Risk for injury related to adverse effect of life-threatening seizures

Risk for fluid volume deficient related to nausea, vomiting, and diarrhea

Colchicine is administered on an hourly basis until pain is relieved, the patient develops severe nausea and diarrhea, or the maximum dose (6 mg) has been administered. Bleeding into the GI or urinary tracts is a potential serious adverse effect of colchicine.