NSAIDs – Pharmacology for Nurses: Practical Applications

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Chapter 44: Anti-Inflammatory Test, NSAIDs, Patient, Pharmacology, Misoprostol

The key terms in this Pharmacology course include Anti-Inflammatory Test, Nurse, Patient, Pharmacology, Pain, Prescription, Misoprostol , Pregnancy, Herbal and Dietary Supplements, Arthritis Pain, Glucosamine Sulfate, Nonsteroidal Antiinflammatory Drugs (NSAIDs), Inhibiting Prostaglandin Production, Colchicine

The nurse would question a prescription to administer misoprostol to a patient with what condition?

Gastroesophageal reflux disease


Chronic obstructive pulmonary disease

Peptic ulcer

Misoprostol is an abortifacient and thus is contraindicated in pregnancy.

The patient asks the nurse about the use of herbal and dietary supplements to treat arthritis pain. What is the appropriate response by the nurse?

“There is evidence that glucosamine sulfate with chondroitin does decrease joint stiffness and pain. Discuss this with your health care provider.”

“High doses of vitamins and minerals have been used for many years to help maintain joint health.”

“Ginkgo biloba has shown tremendous benefit as an antiinflammatory drug and is used to treat the symptoms of pain.”

“There really are no safe herbal treatments for pain. Your best action would be to take your prescription medications.”

There is evidence that patients would benefit from glucosamine sulfate and chondroitin supplements to decrease the pain of osteoarthritis. However, they should always be used in consultation with a health care provider.

What is the mechanism of action of nonsteroidal antiinflammatory drugs (NSAIDs)?

Enhancing pain perception

Inhibiting prostaglandin production

Increasing the supply of natural endorphins

Increasing blood flow to painful areas

Prostaglandins are produced in response to activation of the arachidonic pathway. NSAIDs work by blocking cyclooxygenase (COX-1 and COX-2), the enzyme responsible for conversion of arachidonic acid into prostaglandins. Decreasing the synthesis of prostaglandins results in decreased pain and inflammation.

What nursing diagnosis is appropriate for a patient prescribed colchicine?

Risk for injury related to adverse effect of life-threatening seizures

Risk for fluid volume deficient related to nausea, vomiting, and diarrhea

Risk for infection related to medication-induced leukocytosis

Constipation related to adverse effect of the medication

Colchicine is administered on an hourly basis until pain is relieved, the patient develops severe nausea and diarrhea, or the maximum dose (6 mg) has been administered. Bleeding into the GI or urinary tracts is a potential serious adverse effect of colchicine.

What NSAID would the nurse anticipate administering parenterally for the treatment of acute postoperative pain?





Ketorolac can be administered by injection (intramuscularly or intravenously) and is indicated for the short-term treatment of moderate to severe acute pain.

The nurse is administering probenecid to a patient with recurrent strep throat. The nurse teaches the patient that the reason for taking this medication is for what drug effect?

Prolong the effectiveness of penicillin therapy

Increase uric acid excretion

Inhibit bacterial growth and replication

Prevent the occurrence of gout

Besides its use for the treatment of the hyperuricemia associated with gout and gouty arthritis, probenecid also has the ability to delay the renal excretion of penicillin, thus increasing serum levels of penicillin and prolonging its effect.